A rare primary liver tumour case report: 53-year-old man with primary hepatic leiomyosarcoma

Primary hepatic leiomyosarcoma (PHL) is a very rare primary liver tumour. These tumours usually arise from intrahepatic vascular structures, gallbladder, or ligamentum teres. The pathogenesis of this disease still unknown. We report 53-year-old man with complaints intermittent right upper abdominal pain for one month, decreased appetite, nausea, weight loss, and tea-coloured urination. patient denied any defecation pattern. On physical examination, jaundice was present in both eyes the whole-body skin, tenderness hypochondriacal region, enlarged lumpy surface. laboratory examination demonstrated increased transaminase enzymes bilirubin, while hepatitis B C were negative. underwent several tests tumour markers, such as CA 19-9 50 (<37 U/mL), AFP 1.23 (<5.81 IU/mL), CEA 0.83 (<3 ng/mL). Ultrasound an liver, multiple nodules, cholelithiasis. Meanwhile, abdomen’s computerised tomography (CT) scan shows solid heterogeneity image irregular border segments 1 4b tumoral thrombus inferior vena cava. diagnosis confirmed by biopsy immunohistochemistry (IHC); vimentin smooth muscle actin (SMA) results positive, CD 34, 117, cytokeratin Our diagnosed PHL stage IVa (T4N2M0). particularly poor prognosis. died after month diagnosis. Diagnosis challenging. It based on clinical features, examinations, other supporting investigations.